Eutypenes I (Compound 9) inhibits the secretion of VEGF-A, hampers the activation of VEGFR, and disrupts its downstream Erk/Akt signaling pathway. It also suppresses the migration of HMEC-1 cells and demonstrates anti-angiogenic activity in a Sprague-Dawley rat model.
Molecular Weight:
252.349
Formula:
C15H24O3
Target:
VEGFR|||ERK|||Akt
TN8927
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