Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-beta-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/beta-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of beta-catenin in mouse L cells (IC50=50 nM).
Molecular Weight:
1796.03
Purity:
0.998
CAS Number:
[2247635-23-8]
Formula:
C83H114N18O23S2
Target:
Wnt/beta-catenin
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