ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mzeta (PKMzeta), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMzeta-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 µM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Molecular Weight:
1988.43
Purity:
94.68%
Formula:
C92H158N30O19
Target:
PKC
TP1924L1
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