Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to betac subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.
Molecular Weight:
2370.91
CAS Number:
[222018-18-0]
Formula:
C115H184N30O24
Target:
Interleukin|||Src
TP2008
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