Potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and displays mitogenic and antiapoptotic effects in pancreatic beta-cells.
Molecular Weight:
4983.6
CAS Number:
[100040-31-1]
Formula:
C226H338N60O66S
Target:
IGF-1R
TP2018
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