Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Abeta-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Abeta in vitro. Cyclic AC 253 also available.
Molecular Weight:
2847.11
CAS Number:
[151804-79-4]
Formula:
C122H196N40O39
Target:
Beta Amyloid
TP2078
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