Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
Molecular Weight:
4195.87
CAS Number:
[252642-12-9]
Formula:
C184H297N69O43S
Target:
HIV Protease|||Apelin receptor
TP2093
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