LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a LAP-TGFbeta derivative and a TGF-beta1 antagonist that can cross the blood-brain barrier, inhibits the binding of TSP-1 to LAP and reduces renal interstitial fibrosis and liver fibrosis, inhibits subarachnoid fibrosis by inhibiting TSP-1-mediated TGF-beta1 activity, prevents the occurrence of chronic hydrocephalus and improves long-term neurocognitive deficits after subarachnoid hemorrhage.
Molecular Weight:
572.62
Purity:
99.33%
CAS Number:
[2828433-17-4]
Formula:
C23H43F3N6O7
Target:
TGF-beta/Smad
TP2147
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