Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete alpha-helical conformation with multiple alpha-helical domains separated by non-alpha-helical linkers that are highly conserved in length and amino acid sequence. Nuclear lamins are intermediate filament-type proteins that are the major building blocks of the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted pattern. Lamins also play roles in DNA replication, chromatin organization, the spatial arrangement of nuclear pore complexes, nuclear growth, and anchorage of nuclear envelope proteins.
Molecular Weight:
1001.18
Formula:
C47H76N12O12
Target:
Others
TP2182
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