Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.
Molecular Weight:
3524.1
CAS Number:
[1684439-46-0]
Formula:
C143H244N50O42S4?C2H4O2
Target:
Others|||Calcium Channel|||Natriuretic peptide
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