TAT-CN21 is a potent and highly selective inhibitory peptide for CaMKII with an IC50 of 77 nM. This product achieves cell permeability through the TAT sequence (YGRKKRRQRRR), effectively blocking the catalytic activity of CaMKII and its interaction with the NMDA receptor subunit GluN2B. It plays a critical role in modulating excitotoxicity, reducing glutamate-induced neuronal damage, and serves as a core pharmacological tool for researching ischemic brain injury, neurodegenerative diseases, and synaptic plasticity.
Molecular Weight:
3989.65
Formula:
C169H303N69O43
Target:
CaMK
TP2862
TP2862
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