QPH-FR is a quinoa peptide and acts as an inhibitor of the G protein-coupled receptor 5 (LGR5) that is abundant in leucine repeat sequences. By binding to LGR5, QPH-FR competitively inhibits the formation of the LGR5/RSPO1 complex. This interaction leads to the ubiquitination of FZD receptors by RNF43/ZNRF3, thereby inhibiting the Wnt/beta-catenin signaling pathway and exerting stem cell suppression.
Molecular Weight:
1862.01
Formula:
C81H124N26O25
Target:
Wnt/beta-catenin
TP3080
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