LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin alpha3beta1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.
Molecular Weight:
885.88
CAS Number:
[1095009-44-1]
Formula:
C32H43N11O15S2
Target:
Integrin
TP3270
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