Klotho-derived peptide 1 (KP1 human) can inhibit the interaction between TGF-beta and its receptor TGF-beta receptor 2, suppressing the activation of Smad2/3 and mitogen-activated protein kinase (MAPK) induced by TGF-beta. It shows anti-fibrotic and renal protective effects in mouse models.
Formula:
C149H203N39O43
Target:
p38 MAPK|||TGF-beta/Smad
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