(RXR)4XB is a cell-penetrating peptide that binds to phosphorodiamidate morpholino oligomer (PMO), resulting in a peptide-conjugated PMO (PPMO) and enhancing the delivery of PMO into bacterial cells. The (RXR)4XB-PMO conjugate prevents biofilm formation, inhibits Pseudomonas aeruginosa (with an MIC50 of 0.5-16 µM), and reduces bacterial load in a mouse acute pneumonia model.
Molecular Weight:
1904.37
CAS Number:
[879010-15-8]
Formula:
C81H158N38O15
Target:
Antibacterial
TP3654
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