GCO-(GPO)10-GCOG is a polypeptide containing GPO repeat sequences, exhibiting a collagen-like single collagen triple-helix structure. The cross-linked triple-helix GCO-(GPO)10-GCOG can form collagen-related peptide (CRP) mimetics that closely bind Yersinia adhesin YadA. YadA mediates the adhesion of the human intestinal pathogen Yersinia enterocolitica to collagen and other extracellular matrix components, potentially disrupting host processes mediated by endogenous collagen-binding proteins. GCO-(GPO)10-GCOG is useful for studying YadA-related infections.
Target:
Antibacterial
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