LNSMGQD is a peptide that targets the adhesive interfaces of desmoglein (DSG1 and DSG3) core glycoproteins, interfering with the single peptide (SP) components of DSG trans-interactions. By binding to DSGs, LNSMGQD prevents the loss of DSG trans-interactions induced by autoantibodies, inhibits the activation of p38 MAPK, and prevents keratin filament retraction. It is useful for research into autoimmune skin diseases such as pemphigus vulgaris.
Molecular Weight:
763.82
CAS Number:
[1152066-26-6]
Formula:
C29H49N9O13S
Target:
p38 MAPK
TP3696
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