(RXR)4XB TFA is a cell-penetrating peptide that binds phosphorodiamidate morpholino oligomer (PMO) to create a peptide-conjugated PMO (PPMO) for enhanced delivery into bacterial cells. The (RXR)4XB TFA-PMO complex inhibits biofilm formation, suppresses Pseudomonas aeruginosa with a MIC50 of 0.5-16 µM, and reduces bacterial load in a mouse acute pneumonia model.
Target:
Antibacterial
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