RP-220 is a peptide that targets the NLRP3 enzyme and exhibits anti-inflammatory and anti-apoptotic properties. It inhibits apoptosis of renal tubular epithelial cells caused by alkaline damage by activating the MAPK signaling pathway. In mouse models of acute kidney injury (AKI), RP-220 significantly reduces NLRP3 expression, macrophage infiltration, and renal tissue damage. Additionally, RP-220 is applicable in research on systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN).
Molecular Weight:
2308.61
CAS Number:
[1541177-35-8]
Formula:
C98H166N30O32S
Target:
Apoptosis|||NOD-like Receptor (NLR)|||p38 MAPK
TP3871
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