RP-182 is a synthetic immunomodulatory peptide that exerts antitumor effects by targeting the mannose receptor CD206 on the surface of tumor-associated macrophages (TAM) with a binding affinity (Kd) of 8 µM. It induces a conformational change in the CD206 receptor, which activates NF-kappaB signaling and phagocytosis in TAM with high CD206 expression. RP-182 serves a dual function by activating the canonical NF-kappaB signaling pathway, leading to TNFalpha secretion and autocrine activation of TNF receptor 1 (TNFR1), which subsequently results in caspase 8 activation and apoptosis. This compound is studied in the contexts of pancreatic cancer and melanoma.
Molecular Weight:
1374.68
CAS Number:
[1895883-60-9]
Formula:
C69H103N19O11
Target:
Apoptosis|||NF-kappaB|||Caspase|||TNF
TP3893
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