COG112 is an apoE mimetic peptide linked with antennapedia. It can reduce the induction of nitric oxide (NO) and inhibit the chemokines KC and MIP-2. COG112 decreases the nuclear translocation of NF-kappaB and inhibits the phosphorylation and degradation of IkappaB-alpha. Additionally, COG112 suppresses the inflammatory response to Citrobacter rodentium in mice.
CAS Number:
[1314623-74-9]
Target:
IkappaB/IKK|||NF-kappaB|||NO Synthase|||CXCR
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