8-Br-dGTP (8-Bromo-dGTP) sodium (Compound 5) is a cis isomer of dGTP, characterized as an 8-bromoguanosine nucleotide. This compound is hydrolyzed by the enzyme hMTH1 protein. It inhibits dGTP-activated ADP reduction, exhibiting a Ki value of 56 µM. During DNA synthesis, 8-Br-dGTP sodium presents no significant genotoxicity or mutagenic potential.
Target:
Nucleoside Antimetabolite/Analog
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