NH2-PEG1-Val-Cit-PAB-OH, CAS [[2055024-63-8]] Preis auf Anfrage

Product Overview

• Article Name: NH2-PEG1-Val-Cit-PAB-OH, CAS [[2055024-63-8]] Preis auf Anfrage
• Biozol Catalog Number: TGM-TYD-01967
• Supplier Catalog Number: TYD-01967
• Alternative Catalog Number: TGM-TYD-01967-10MG,TGM-TYD-01967-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker with a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB group facilitates conjugation reactions with groups like PNP for binding drug payloads. The primary amine is versatile in participating in reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and more specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.

Product Properties

• Molecular Weight: 494.584
• CAS Number: [2055024-63-8]
• Formula: C23H38N6O6
• Target: ADC Linker

Images

TYD-01967