EN1033 is a covalent immunomodulatory transcription factor 5/8 (IRF5/8) degrader. It disrupts and degrades IRF5 and IRF8 by covalently targeting cysteine residues C28 and C223, thereby inhibiting their pro-inflammatory transcriptional activity, such as reducing mRNA levels of IL1A, IL1B, and CCL2. EN1033 is applicable in research of autoimmune and inflammatory diseases.
Molecular Weight:
242.32
CAS Number:
[2193367-28-9]
Formula:
C15H18N2O
Target:
Interleukin|||CCR
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