Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB2 is a member of the ovarian tumor domain family. Not much is known about the biological function of this enzyme, but it may deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.
