USP9X belongs to the ubiquitin-specific protease (USP) family. USP9X has been found to deubiqitinate more than a dozen of substrates including mcl1, survivin, SMAD4, SMN and Itch. USP9X is located on the X chromosome, but it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Also, Usp9X is unregulated in various cancers. The catalytic domain contains the region from amino acid 1531 to amino acid 1972.
