Maturation of SARS-CoV-2 virus requires two proteases, 3C-like protease (3CLP) and Papain-like protease (PLP), to cleave the large polyproteins 1a and 1ab to generate functional proteins. which is essential for genome replication and Coronavirus virion production. Both proteases are encoded by the polyproteins. 3CLP is a cysteine protease and forms a homodimer. 3CLP is the drug target of PF-17321332, a main component of the oral anti-Covid-19 drug Paxlovid. PLP is also a cysteine protease that cleaves polyproteins and has deubiquitinating and deISG15ylating activities. PLP is also a potential anti-Covid-19 drug target. The recombinant SARS-CoV-2 papain-like protease contains the catalytic domain from Glu746 to Lys1060.
Molecular Weight:
36 kDa
Buffer:
20 mM Tris, pH7.6 at 4 0C, 150 mM NaCl, 4mM TCEP, 10% Glycerol and 0.01% Tween-20
Source:
E. coli recombinant
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