4E Binding Protein 1, phosphorylated (Thr37/46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP), Clone: [9B142236B4], Rabbit, Monoclonal
Biozol Catalog Number:
USB-0004-18J
Supplier Catalog Number:
0004-18J
Alternative Catalog Number:
USB-0004-18J-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
FC, IF, IHC, WB
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding Thr37 and Thr46 of mouse 4E-BP1
When bound to eIF4E, 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation. Upon hyperphosphorylation of 4E-BP1 this interaction is disrupted and cap-dependent translation is activated. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regu