4E Binding Protein 1, phosphorylated (Thr37/46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP), Rabbit
Catalog Number:
USB-0004-19
| Article Name: |
4E Binding Protein 1, phosphorylated (Thr37/46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP), Rabbit |
| Biozol Catalog Number: |
USB-0004-19 |
| Supplier Catalog Number: |
0004-19 |
| Alternative Catalog Number: |
USB-0004-19-100 |
| Manufacturer: |
US Biological |
| Host: |
Rabbit |
| Category: |
Antikörper |
| Application: |
WB |
| Immunogen: |
Synthetic phosphopeptide corresponding to residues surrounding Thr37 of mouse 4E-BP1 and Thr46 of mouse 4E-BP1. |
| 4E-BP1 (also known as PHAS-1) normally binds eIF4E, inhibiting cap-dependent translation. Hyperphosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation (1). The PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 (2,3 |
| UniProt: |
Q13541 |
| Purity: |
Purified by Protein A and peptide affinity chromatography. |
| Form: |
Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. |
