4E Binding Protein 1, non-phosphorylated (Thr46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP), Clone: [7H187D12], Rabbit, Monoclonal

Product Overview

• Article Name: 4E Binding Protein 1, non-phosphorylated (Thr46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP), Clone: [7H187D12], Rabbit, Monoclonal
• Biozol Catalog Number: USB-0004-20B
• Supplier Catalog Number: 0004-20B
• Alternative Catalog Number: USB-0004-20B-100
• Manufacturer: US Biological
• Host: Rabbit
• Category: Antikörper
• Application: FC, IF, WB
• Immunogen: Synthetic peptide corresponding to residues surrounding Thr46 of human 4E-BP1.

Product Description

4E-BP1 (also known as PHAS-1) when bound to eIF4E, inhibits cap-dependent translation. Upon hyperphosphorylation of 4E-BP1 this interaction is disrupted and cap-dependent translation is activated (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase

Product Properties

• Clonality: Monoclonal
• Clone Designation: [7H187D12]
• Purity: Purified
• Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 0.02% sodium azide, 50% glycerol.