Acetylisoniazide is an antimicrobial agent that belongs to the group of enzyme in1gducers. It is a prodrug that is hydrolyzed by esterases in the body to picolinic acid and acetyl-CoA. Acetylisoniazide has been shown to inhibit the growth of bacteria, yeast, and fungi that are resistant to other antimicrobial agents. This drug also inhibits the production of pyrazinoic acid, a metabolite of tryptophan synthesis and an activator of macrophages. Acetylisoniazide has been shown to have a synergistic effect with isoniazid for the treatment of tuberculosis. The polymerase chain reaction (PCR) method was used for this study. Acetylisoniazide binds to human serum albumin, which decreases its solubility in water and affects its reactivity with fluorescence probes. The matrix effect was investigated using rat liver microsomes as a model system. Synonyms: 2-Acetylhydrazide-4-pyridinecarboxylic Acid, 1-Acetyl-2-isonicotinoylhydrazine, Acetylisoniazide, N-Acetyl-N-isonicotinoylhydrazine, N-Acetylisoniazid, N-Acetylisonicotinylhydrazide, N-Monoacetylisoniazid, NSC 36084 CAS No: 1078-38-2 Molecular Formula: C8H9N3O2 Molecular Weight: 179.18 Appearance: White to off-white solid Purity: 98% Melting Point: 158-159C Solubility: DMSO, Methanol Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
179.18
Purity:
98%
Form:
White to off-white solid
CAS Number:
[1078-38-2]
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