L-Alanosine is an antibiotic derived from bacterium S. alanosinicus with antineoplastic activity in cells deficient in methylthioadenosine phosphorylase (MTAP) (mean IC50 = 4.8uM and 10uM in T-ALL and CAK-1 cells, respectively). L-Alanosine inhibits adenylosuccinate synthetase to disrupt de novo purine biosynthesis, inhibiting cellular metabolism in MTAP-deficient tumor cells.3,4,5 Synonyms: 3-(Hydroxynitrosoamino)-L-alanine, L-2-Amino-3-(N-nitroso)hydroxylaminopropionic Acid, Alanosine, NSC 153353, NSC 529469, SDX 102 CAS No: 5854-93-3 Molecular Formula: C3H7N3O4 Molecular Weight: 149.11 Purity (TLC): 95% Appearance: White to off-white solid Melting Point: 179C (dec.) Solubility: Aqueous Acid, Aqueous Base: 100mM HCl: 1mg/ml 100mM NaOH: 1mg/ml Water: 1mg/ml Storage and Stability: Lyophilized product is stable for 6 months after receipt at -20C under inert atmosphere. Reconstitute with HCl, NaOH or sterile water. LIQUID IS STABLE FOR 24 HOURS. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight:
149.11
CAS Number:
[5854-93-3]
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