Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Synonyms: 17-Demethoxy-17-(2-propenylamino)geldanamycin, 17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)-17-desmethylgeldanamycin, 17-Demethoxy-17-allylaminogeldanamycin, 17AAG, CP 127374, KOS 953, NSC 330507, Tanespimycin, 17-AAG CAS Number: 75747-14-7 Molecular Formula: C31H43N3O8 Molecular Weight: 585.69 Appearance: Supplied as a dark purple to very dark red powder. Melting Point: >194C (dec.) Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
585.69
Purity:
98%
Form:
Supplied as a dark purple to very dark red powder.
CAS Number:
[75747-14-7]
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