| Labeled Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IkappaB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Synonyms: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6, (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6, C Yellow 15-d6, C.I. 75300-d6, Curcuma-d6, Curcumine-d6, Diferuloylmethane-d6, Haidr-d6, Halad-d6, Haldar-d6, Ukon-d6 CAS Number: 1246833-26-0 Molecular Formula: C21H14D6O6 Molecular Weight: 374.42 Purity: Chemical Purity: ~98%, Isotopic Purity: ~99% Form: Orange to dark orange solid Melting Point: 184-186C (lit) Solubility: Chloroform (Slightly Sonicated), DMSO (Slightly) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis Normalized Intensity: d0=0.03%, d1=0.10%, d2=0.00%, d3=0.12%, d4=0.06%, d5=0.00%, d6=99.69% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C for 6 months after time of receipt. |
