It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen. Melting Point: 41-45C Solubility: Chloroform (Slightly), Methanol (Slightly) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis Water: ~7.0% TLC Conditions: SiO2, Dichloromethane: Methanol = 9:1, Visualized with UV, Ninhydrin and KMnO4, Single spot, Rf=0.45 Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
279.1
Purity:
~90%
Form:
White to Off-White Solid
CAS Number:
[6055-19-2]
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