Methicillin sodium is a narrow spectrum beta-lactam antibiotic related to Penicillin. beta-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBPs are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to beta-lactams is commonly due to cells containing plasmid encoded beta-lactamases. Methicillin is mostly resistant to beta-lactamases. Methicillin targets primarily the cell wall of Gram positive organisms especially Staphylococcus aureus. Water (Karl Fisher): 10% Melting Point: 196197C Optical Rotation: +225 Solubility: Water: ~0.3mg/ml Acetone: 0.35mg/ml Ethanol: 40mg/ml MIC: Staphylococcus aureus: 0.5ug/ml-32ug/ml Storage: -20C
Molecular Weight:
402.4
Form:
Supplied as a white to off-white powder.
CAS Number:
[132-92-3]
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