Inhibitor of bacterial DNA synthesis. Nalidixic acid is the first of the synthetic quinolone antibiotics. It is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom.[1] Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.[1] Used clinically from 1967.[1] Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner, that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. Form: Crystalline Powder Melting Point: 229-230C Solubility: Chloroform, Ethanol, Methanol, Toluene
Molecular Weight:
237.27
Form:
Crystalline Powder
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