PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Synonyms: N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methylmethanesulfonamide, N-Methyl-N-[2-[[[2-[(2-oxo- 2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide, PF 431396 CAS Number: 717906-29-1 Molecular Weight: 506.5 Molecular Formula: C22H21F3N6O3S Solubility: DMSO (Slightly) Appearance: Supplied as a gray solid. Melting Point: >214C (dec.) Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Pfizer Compound
Molecular Weight:
506.5
Form:
Supplied as a gray solid.
CAS Number:
[717906-29-1]
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