| A parasympathomimetic, specifically, a reversible cholinesterase inhibitor obtained from the Calabar bean, used to treat glaucoma and delayed gastric emptying. Physostigmine is an alkaloid and noted to act as a potent and reversible inhibitor of cholinesterase. Physostigmine is also reported to form a slowly degrading carbamylated enzyme complex with AChE (acetylcholinesterase). This compound has been used as a positive control in a study investigating acetylcholinesterase inhibitors for potential antihelminthic drug targets. Synonyms: (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol Methylcarbamate Ester, Eserine, Synapton, Cogmine, Eserine, Esromiotin, MCV 4484, NIH 10421, NSC 30782, (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate CAS Number: 57-47-6 Molecular Formula: C15H21N3O2 Molecular Weight: 275.35 Appearance: White to pale orange solid Purity: 99% Melting Point: 102-106C Solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Ethanol (Slightly), Methanol Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
