TAK 375 is a very high affinity and selective melatonin agonist (Ki values are 14 and 112pM for human MT1 and MT2, respectively). Selective for human MT1 and MT2 over hamster MT3 and a range of other targets including benzodiazepine, opiate and dopamine receptors, ion channels and transporters. Accelerates return to normal circadian rhythm in rats after phase shift, without affecting learning and memory. Also reduces infarct size in rat heart in vitro post ischemia-reperfusion. Synonyms: N-[-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide, TAK-375, Rozerem CAS No: 196597-26-9 Molecular Formula: C16H21NO2 Molecular Weight: 259.34 Purity: 98% Appearance: White to off-white solid Melting Point: 108-110C (lit) 1H NMR Spectrum: Conforms to structure Storage and Stability: Powder may be stored at -20C. Stable for 6 months after receipt.
Molecular Weight:
259.34
CAS Number:
[196597-26-9]
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