Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. Synonyms: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine, ICI 47699, Mammaton, Novaldex, Tamoxifen, Z-Tamoxifen CAS No: 10540-29-1 Molecular Formula: C26H29NO Molecular Weight: 371.52 Purity (HPLC): 98% Appearance: White to off-white powder 1H-NMR: Conforms to structure Melting Point: >92C (dec.) (lit) Storage and Stability: Store at -20C. Stable for 12 months after receipt.
Molecular Weight:
371.52
CAS Number:
[10540-29-1]
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