Valosin Containing Protein (VCP) BioAssay(TM) ELISA Kit (Rat) (Transitional Endoplasmic Reticulum ATPase, TER ATPase, 15S Mg(2+)-ATPase p97 Subunit, Valosin-containing Protein)

Product Overview

• Article Name: Valosin Containing Protein (VCP) BioAssay(TM) ELISA Kit (Rat) (Transitional Endoplasmic Reticulum ATPase, TER ATPase, 15S Mg(2+)-ATPase p97 Subunit, Valosin-containing Protein)
• Biozol Catalog Number: USB-028810
• Supplier Catalog Number: 028810
• Alternative Catalog Number: USB-028810-96
• Manufacturer: US Biological
• Category: Kits/Assays

Product Description

Valosin Containing Protein (VCP) BioAssay(TM) ELISA Kit (Rat) is a sandwich enzyme immunoassay for in vitro quantitative measurement of VCP in rat tissue homogenates and other biological fluids. Valsolin Containing Protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. p97/VCP (valosin containing protein) belongs to the AAA ATPase family, predicted molecular weight 97kD. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinsons Disease. Detection Range: 0.312-20ng/ml Sensitivity: 0.115ng/ml Storage and Stability: Desiccation recommended. The Standard, Detection Reagent A, Detection Reagent B and the 96-well strip plate should be stored at -20C upon receipt. Store all other reagents at 4C. Stable for 6 months after receipt of order.