C-Cbl, active, Recombinant, Human, GST-Tag (E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, Signal transduction protein CBL, CBL2, RNF55)
Catalog Number:
USB-029430
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| Article Name: | C-Cbl, active, Recombinant, Human, GST-Tag (E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, Signal transduction protein CBL, CBL2, RNF55) |
| Biozol Catalog Number: | USB-029430 |
| Supplier Catalog Number: | 029430 |
| Alternative Catalog Number: | USB-029430-10 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia. Recombinant protein corresponding to full length human c-Cbl, fused to GST-tag at N-terminal, expressed by baculovirus in Sf21 insect cells. Swiss Prot Number: P22681 Molecular Weight: ~127kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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