Rho Kinase Inhibitor (H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor), CAS [[872543-07-6]]

Product Overview

• Article Name: Rho Kinase Inhibitor (H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor), CAS [[872543-07-6]]
• Biozol Catalog Number: USB-029603
• Supplier Catalog Number: 029603
• Alternative Catalog Number: USB-029603-1,USB-029603-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK, Ki=1.6nM). Inhibits other serine/threonine kinases only at higher concentrations (Ki=630nM for PKA, 9.27 uM for PKC, and 10.1uM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC50=2.5uM). Reported to be a more potent and selective inhibitor than Y-27632. Synonyms: H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor, Dimethylfasudil (diMF, H-1152P) CAS No: 872543-07-6 Molecular Formula: C16H21N3O2S 2HCl Molecular Weight: 392.3 Solubility: H2O (5mg/ml) or Methanol (5mg/ml) Form: Supplied as a white solid. Primary Target: ROCK Purity: 95% (HPLC) Appearance: Supplied as a white solid. Storage and Stability: Store at -20C under inert atmosphere. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 392.3
• Purity: 95% (HPLC)
• Form: Supplied as a white solid.
• CAS Number: [872543-07-6]