bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumor suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 µM for PTPbeta and 25.3 µM for PTP-1beta. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury. Synonyms: Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V). CAS Number: 722494-26-0 Molecular Formula: K2[VO(O2)2C6H4NO3] Molecular Weight: 347.24 Form: Supplied as a yellow crystalline powder. Purity: 95% (51V-NMR) Solubility: Soluble in DMSO and water. Note: Not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO. Storage and Stability: Short Term Storage: +4C Long Term Storage: -20C May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Moisture and light sensitive.
Molecular Weight:
347.24
Purity:
95% (51V-NMR)
Form:
Supplied as a yellow crystalline powder.
CAS Number:
[722494-26-0]
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