Potent and selective endothelin receptor A (ETA) antagonist. Suppresses the ET-1-induced decrease of LPL activity. Shows protective effects in ischemic acute renal failure. Neuroprotective. Anti-hypertensive. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation. Cardiovascular agent. Reduces myocardial infarct size and oxidant injury. Source: Synthetic Synonyms: Endothelin Receptor A Antagonist BQ-123 CAS Number: 136655-57-7 Peptide Sequence: Cyclo (D-Trp-D-Asp-Pro-D-Val-Leu) Molecular Weight: 632.7 Molecular Formula: C31H42N6O7Na Solubility: Water Net Peptide Content (AAA): 73.1% Appearance: Supplied as a white solid. Purity: 98% (HPLC) Storage and Stability: Store at 4C short term. After reconstitution, prepare aliquots and store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
632.7
Purity:
98% (HPLC)
Form:
Supplied as a white solid.
CAS Number:
[136553-81-6]
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