Key constituent of St. Johns wort. Shows properties of potential pharmacological interest, including anti-bacterial, anti-malarial, anti-inflammatory, anti-cancer and anti-angiogenic effects. Anti-depressant and anxiolytic compound. Specific activator of TRPC6 channels. Inhibits the re-uptake of neurotransmitters in synapses (serotonin, norepinephrine, dopamine, GABA, glutamate). Activator of the pregnane X receptor (PXR). Regulates expression of the cytochrome P450 CYP3A4 and CYP2C9 and hepatic drugs metabolism. Potential anti-Alzheimer compound. Potent SIRT1 (sirtuin 1) and SIRT2 (sirtuin 2) inhibitor. Synonyms: (1R,5R,6R,7S)-2-Hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-2-ene-4,9-dione . DCHA CAS Number: 238074-03-8 Source: Isolated from St. Johns wort (Hypericum perforatum) Molecular Weight: 718.1 Molecular Formula: C35H51O4C12H24N Solubility: 100% ethanol, methanol or DMSO. Appearance: Supplied as a white to off-white solid. Purity: 97% (HPLC) Note: The DCHA salt stabilizes hyperforin which normally has only a short shelf life. Storage and Stability: Store at -20C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
718.1
Purity:
97% (HPLC)
Form:
Supplied as a white to off-white solid.
CAS Number:
[238074-03-8]
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