Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay). Synonyms: rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide CAS Number: 1127442-82-3 Molecular Formula: C25H19N3O3 Molecular Weight: 409.4 Purity: 98% Appearance: White to off-white solid. Solubility: Soluble in DMSO or DMF. Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, dissolve first in DMSO and then dilute with the aqueous buffer of choice. Solubility in a 1:3 solution of DMSO:PBS (pH 7.2) (~0.25mg/ml). It is recommended to use fresh aqueous solutions and not to store them for more than one day. Storage and Stability: Short-term Storage: +4C Long-term Storage: -20C Stable for at least 2 years after receipt when stored at -20C.
Molecular Weight:
409.4
Purity:
98%
Form:
White to off-white solid.
CAS Number:
[1127442-82-3]
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