Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation. Synonyms: Ruboxistaurin CAS No: 169939-93-9 Molecular Weight: 505.1 Molecular Formula: C28H28N4O3HCl Solubility: DMSO, slightly soluble in 100% ethanol or water. Method for Determining Identity: Proton NMR Appearance: Supplied as a red solid. Purity: 98% (HPLC) Storage and Stability: Store at -20C. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
505.1
Purity:
98% (HPLC)
Form:
Supplied as a red solid.
CAS Number:
[169939-93-9]
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