Highly reactive, thiol-specific spin-label. Specific conformational probe of thiol site structure by its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study. Used to label cysteine residues in proteins (site-directed labeling, SDS-labeling). Allows protein structure and protein dynamics determination as well as the study of protein-protein and protein-oligonucleotide interactions. Synonyms: Mts-SL, MTSL, (1-Oxyl-2,2,5,5-tetramethylpyrroline-3- methyl)methanethiosulfonate, Otmpmms CAS Number: 81213-52-7 Molecular Weight: 264.3 Molecular Formula: C10H18NO3S2 Solubility: Ethanol, methanol, DMSO, acetonitrile or acetone. MTSSL can be used in aqueous solution at concentrations as high as 10mM. However, MTSSL initially must be dissolved in an organic solvent such as DMSO or acetonitrile (100mM or higher) and then the initial stock solution can be diluted 10-100 fold in water-based buffers. Sonication and heating is not recommended to dissolve MTSSL. Appearance: Supplied as a yellow crystalline solid. Purity: 98% (HPLC) Storage and Stability: Store at 4C for short term only. Protect from light. Stable for 12 months after receipt when stored at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
264.3
Purity:
98% (HPLC)
Form:
Supplied as a yellow crystalline solid.
CAS Number:
[81213-52-7]
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